| Name: | Frank Rösch |
| Adress: | Institute of Nuclear Chemistry; Fritz-Strassmann-Weg 2 Johannes Gutenberg-University Mainz, D-55128 Mainz, Germany Phone: 06131-392 5302 Fax : 06131-392 4692 @: frank.roesch@uni-mainz.de |
| Education and Training | |
| 1955 | born in Chemnitz; Germany, 15.10.1955 |
| 1961-1974 | school in Hoyerswerda, Germany |
| 1976-1981 | Studying chemistry: Technical University (TU) Dresden, Germany |
| 1980-1981 | Dipl.-Chem. TU Dresden, Faculty of Chemistry, Section Radiochemistry: Production of 211At and investigations on cationic species of astatine and their reactions |
| 1981-1984 | TU Dresden, Faculty of Chemistry, Section Radiochemistry: |
| 1984 | Ph.D. (Dr. rer. nat.): Faculty for Mathematics and Sciences, TU Dresden: On the Chemistry of At(I)-Complex formations |
| 1984-1987 | Research fellow: Joint Institute for Nuclear Research, Dubna, Sowjet Union, Laboratory for Nuclear Problems |
| 1987-1991 | Central Research Institute of the Academy of Sciences (ZfK) Rossendorf , Department of Radioactive Isotopes – Nuclear Pharmaca II |
| 1988 | Dissertation (Dr.sc.nat.): Faculty for Mathematics and Sciences, TU Dresden: Basics and perspectives of the continuous electromigration measurement of  -emitting radionuclides in homogeneous aqueous electrolytes free of supporting materials |
| 1989-1991 | “Privatdozent” TU Dresden; Teaching Postgradual Radiochemistry |
| 1992-1995 |
Institute of Nuclear Chemistry; Research Centre Jülich GmbH, Germany
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| Present Positions | |
| since 1996 | Professor (C4) for Nuclear Chemistry, Institute of Nuclear Chemistry, Johannes Gutenberg-University Mainz, Germany |
| since 1997 | Speaker of the Interdisciplinary Network of PET research of the Johannes Gutenberg-University Mainz, Germany |
| since 2000 | Speaker of the Centre of Competency on PET-research of the state of Rheinland-Pfalz, Germany |
| since 2000 | Co-ordinator, working groub leader or vice-chair of various COST actions (EUROPEAN COOPERATION IN SCIENCE AND TECHNOLOGY) related to radiometals and their medical application: D18: LANTHANIDE CHEMISTRY FOR DIAGNOSIS AND THERAPY, D38: METAL-BASED SYSTEMS FOR MOLECULAR IMAGING APPLICATIONS BMC0607: FROM DOSIMETRY TO BIOLOGICAL EFFECT: RADIOBIOLOGY AS GUIDE TO CLINICAL PRACTICE IN NUCLEAR MEDICINETD1004: THERAGNOSTICS IMAGING AND THERAPY: AN ACTION TO DEVELOP NOVEL NANOSIZED SYSTEMS FOR IMAGING-GUIDED DRUG DELIVERY |
| since 2000 | Member of the working group Radiopharmaceuticals of the The Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, Germany) |
| since 2001 | Co-ordinator of the International Student Exchange Program for Nuclear Chemistry / Radiopharmaceutical Chemistry between the University Mainz and the Brookhaven National Laboratory, USA |
| since 2003 2006-2009 2012-2015 |
Expert of the IAEA (International Atomic Energy Agency, Vienna) Managing director of the Institute of Nuclear Chemistry Managing director of the Institute of Nuclear Chemistry |
| Scientific publications and books | |
| papers | |
| since 1984 | ca. 300 in peer-review journals |
| book chapters | |
| 1999 | Hamkens H, Rösch F. FDG: Biochemisches Konzept und radiochemische Synthese. In: HJ Wieler (ed.), PET in der klinischen Onkologie, Steinkopff Verlag, Darmstadt, 59-70 |
| 1999 | Rösch F. Aktuelle Entwicklungen 18F-markierter onkologischer PET-Tracer. In: HJ Wieler (ed.), PET in der klinischen Onkologie, Steinkopff Verlag, Darmstadt, 71-84 |
| 1999 | Stolz B, Bruns C, Albert R, Rösch F, Smith-Jones P, Raulf F, Hoyer D, Weckbecker G. Somatostatin receptor-targeted radiotherapy – preclinical proof of concept. In: Octreotide: The Next Decade, Ed S W J Lamberts, BioScientifica Ltd. (1999) pp 1- |
| 2000 | Rösch F, Wester HJ, Degrado T.R. Current developments of 18F-labeled PET-tracers in oncology. In: Wieler HJ, Coleman RE(eds.), PET in Clinical Oncology, Steinkopff, Darmstadt, 55-66 |
| 2000 | Hamkens H, Rösch F. FDG: Biochemical concept and radiochemical synthesis. In: Wieler HJ, Coleman RE (eds.), PET in Clinical Oncology, Steinkopff, Darmstadt, 67-78 |
| 2003 | Novgorodov AF, Rösch F, Korolev NA. Radiochemical Separations by Thermochromatography. in A Vértes, S Nagy, Z Klencsár (eds.), Handbook of Nuclear Chemistry – Vol. 5, pp 227-259, 2003, Kluwer Academic Publishers, The Netherlands |
| 2003 | Rösch F, Knapp FF (Russ). Radionuclide Generators. in A Vértes, S Nagy, Z Klencsár, F Rösch (eds.), Handbook of Nuclear Chemistry – Vol. 4, pp 81-118, 2003, Kluwer Academic Publishers, The Netherlands |
| 2004 | Rösch F, Forsell-Aronsson E. Radio-lanthanides in Nuclear Medicine. In: Metal Ions and Their Complexes in Medication, A. Sigel, H. Sigel, Eds. Vol. 42. pp. 77-108, M. Dekker, Inc., New York / Basel |
| 2006 | Rösch F, Knapp FF. Radionuclide Generators. In: Vértes A, Nagy S, Klencsár Z, Lovas RG, Rösch F (eds.): Handbook of Nuclear Chemistry, Second edition, Vol. 4, pp 1935-1976, Springer, Berlin / Heidelberg |
| 2006 | Novgorodov AF, Rösch F, Korolev NA. Radiochemical separations by thermochromatography. In: Vértes A, Nagy S, Klencsár Z, Lovas RG, Rösch F (eds.): Handbook of Nuclear Chemistry, Second edition, Vol. 5, pp 2429-2458,Springer, Berlin / Heidelberg |
| 2006 | Rösch F, Gründer G, Schreckenberger M, Dannhardt G. Radiopharmazeutische Entwicklungen für die Molekulare Bildgebung von Prozessen im Zentralen Nervensystem. Healthy Academy 01/2006, pp. 38-53. in: Molecular Imaging. Innovationen und Visionen in der medizinischen Bildgebung. Herausgeber: W Niederlag, H U Lemke, W Semmler, C Bremer. |
| 2008 | Rösch F. Radiochemistry and Radiopharmaceutical Chemistry for Medicine. In: Encyclopedia of Life Support Systems, EOLSS Publishers Co Ltd, Oxford , UK |
| 2010 | Rösch F, Filosofov DV. Production, radiochemical processing and quality evaluation of Ge-68, In: IAEA-TEC-DOC Radioisotopes and radiopharmaceuticals, Series 2: Production of Long Lived Parent Radionuclides for Generators: 68Ge, 82Sr, 90Sr and 188W, International Atomic Energy Agency, Vienna. ISSN 2077–6462; no. 2, STI/PUB/1436, ISBN 978–92–0–101110–7. |
| 2011 | Rösch F, Piel M. Radiochemie / tracer. In: Mohnike W, Hör G, Schelbert H (eds.), PET/CT-Atlas: Interdisziplinäre onkologische, neurologische und kardiologische PET/CT-Diagnostik, 2. edition, Springer, Berlin / Heidelberg, pp. 35-72. |
| 2012 | Piel M, Rösch F. Generator-based radiopharmaceuticals for PET dosimetry before, during, and after endoradiotherapy. In: G Gründer (ed.) Molecular imaging in the clinical neurosciences. Humana Press / Springer, New York / Heidelberg / Dordrecht / London, pp. 83-94. |
| 2014 | Rösch F, Baum RP. Radiopharmaceutical chemistry. In: Baum RP (ed.) Therapeutic Nuclear Medicine. Springer, New York /Heidelberg / Dordrecht / London, pp. 41-73. |
| Awards | |
| 1986 | Scientific Award of the Technical University Dresden |
| 1988 | Scientific Award of the Central Research Institute of the Academy of Sciences (ZfK) Rossendorf |
| 2006 | Prize for Invention: Investitions- und Strukturbank Rheinland-Pfalz |
| 2010 | Prize for Invention: Investitions- und Strukturbank Rheinland-Pfalz |
| 2015 | Invited Speaker to the Australian and New Zeeland Society of Nuclear Medicine |
| 2015 | VIKRAM SARAHBAI oration of the Society of Nuclear Medicine, India |
| Main scientific achievements | |
| 1992-1994 | Invention and introduction of the positron emitter 94mTc |
| 1994-1997 | Invention and introduction of the positron emitter 86Y and its first use as THERANOSTICS vs. 90Y-anlogue therapeuticals |
| 2000 | Invention of the production pathway of carrier-free 177Lu via the 176Yb-route |
| 2004 | Establishment of the cation exchange-based 68Ge/68Ga radionuclide generator processing |
| 2004 | Invention and introduction of the 44Ti/Sc Generator |
| 2006-2009 | Transfer of 68Ge/68Ga generator technologies and medical applications to: Bad Berka (Germany), New Delhi (India), Santiago (Chile), Melbourne, Freemantle and Sydney (Australia) |
| since 2007 | Organisation of several international Training schools on PET-radionuclide generators for trivalent metals: 68Ge/68Ga and 44Ti/44Sc at Mainz and elsewhere |
| 2011 | Together with Prof. Richard Baum initiator and coordinator of a series of World Congresses on Gallium-68 and Peptide Receptor RadioNuclide Therapy (PRRNT): 1st World Congress: Bad Berka, Germany, June 23-26, 2011 |
| 2011-now | Invention and introduction of a new class of radiolabeled bisphosphonates for imaging and therapy of bone metastases |
| 2014 | Publication of a teaching book for bachelor students and professionals working with radioactivity, including nuclear medicine: Rösch F: Nuclear and Radiochemistry. Volume I: Introduction. Walter De Gruyter, Berlin/Boston |
| Patents | |
| since 1984 | More than 30 national and international patents |
| Research | |
| from | basic inorganic radiochemistry |
| and | physic-chemistry of of radio-metals in aqueous solutions |
| to | production of radionuclides at cyclotrons and reactors (such as. e.g. suggesting the positron emitters 86Y and 94mTc or creating the pathway of nca. 177Lu via the 169Yb(n,g) route) including measurements of nuclear data and development of radiochemical separation methods |
| and | design of various radionuclide generator systems (recently the post-processing of the 68Ge/68Ga-system or the realization of the 44Ti/44Sc generator) |
| plus | Synthesis of new radiopharmaceuticals for theranostics, but also 18F-labelled tracers for neuro research |
| Training and Teaching | |
| since 1987 | Teaching nuclear and radiochemistry and radiopharmaceutical chemistry at the Universities of Dresden, Cologne and Mainz |
| since 1990 | Supervising Diploma, Bachelor and Master students from various countries (more than 50) |
| since 1994 | Supervising PhD students from various countries (more than 30) design of various radionuclide generator systems (recently the post-processing of the 68Ge/68Ga-system or the realization of the 44Ti/44Sc generator) |
| since 2006 | Member of various CRP projects of the IAEA, a United Nations Organisation |
| since 2010 | International expert of the IAEA, a United Nations Organisation, with missions to several countries |
| 2003 and 2001 (second edition) |
Publication of a scientific book for professionals working with radioactivity: Vértes A, Nagy S, Klencsár Z, Lovas RG, Rösch F (eds.), Handbook of Nuclear Chemistry. Second edition, 3324 p., 6 Volumes, Springer, Berlin-Heidelberg |
| 2014 | Publication of a teaching book for bachelor students and professionals working with radioactivity, including nuclear medicine: Rösch F: Nuclear and Radiochemistry. Volume I: Introduction. Walter De Gruyter, Berlin/Boston |
| 2016 | Publication of a teaching book for bachelor students and professionals working with radioactivity, including nuclear medicine: Rösch F: Nuclear and Radiochemistry. Volume II: Modern applications of nuclear Chemistry. Walter De Gruyter, Berlin/Boston |