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Topic: The development and immunological evaluation of synthetic antitumor vaccines which are based on tumor associated MUC1-glycopeptides
Veröffentlichungen:
8. "Immunization with a synthetic human MUC1 glycopeptide vaccine against tumor-associated MUC1 breaks tolerance in human MUC1 transgenic mice."
N. Stergiou, M. Glaffig, H. Jonuleit, E. Schmitt, H. Kunz, ChemMedChem 2017, accepted article.
(DOI: 10.1002/cmdc.201700387)
7. "Immunogenicity of a fully synthetic MUC1-glycopeptide antitumor vaccine enhanced by poly(I:C) as TLR3-activating adjuvant”
M. Glaffig, N. Stergiou, E. Schmitt, H. Kunz, ChemMedChem 2017, 12, 722-727.
(DOI: 10.1002/cmdc.201700254)
6. „Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers”
M. Glaffig, B. Palitzsch, N. Stergiou, C. Schüll, D. Straßburger, E. Schmitt, H. Frey, H. Kunz, Org. Biomol. Chem. 2015, 13, 10150-10154.
(DOI: 10.1039/C5OB01255D)
5. Review: “Mucin Glycopeptide-Protein Conjugates – Promising Antitumor Vaccine Candidates”
B. Palitzsch, M. Glaffig, H. Kunz, Isr. J. Chem. 2015, 55, 256-267.
(DOI: 10.1002/ijch.201400131)
4. "CpG-loaded Multifunctional Cationic Nanohydrogel Particles as Self‐Adjuvanting Glycopeptide Antitumor Vaccines"
S. Hartmann, L. Nuhn, B. Palitzsch, M. Glaffig, N. Stergiou, B. Gerlitzki, E. Schmitt, H. Kunz, R. Zentel, Adv. Healthcare Mater. 2015, 4, 522-527.
(DOI: 10.1002/adhm.201400460)
3. „A fully synthetic four-component antitumor vaccine consisting of a mucin glycopeptide antigen combined with three different T-helper-cell epitopes“
B. Palitzsch, S. Hartmann, N. Stergiou, M. Glaffig, E. Schmitt and H. Kunz, Angew. Chem. Int. Ed. 2014, 51, 14245-14249.
(DOI: 10.1002/anie.201406843)
2. Buchkapitel: "Tumour‐associated glycopeptide antigens and their modification in anticancer vaccines“
S. Hartmann, B. Palitzsch, M. Glaffig, H. Kunz, Specialist Periodical Report, Carbohydrate Chemistry: Chemical and Biological Approaches, The Royal Society of Chemistry, Cambridge, 2014, 40, 506-532.
(DOI: 10.1039/978184973998600506)
1. “A Fully Synthetic Glycopeptide Antitumor Vaccine Based on Multiple Antigen Presentation on a Hyperbranched Polymer“
M. Glaffig, B. Palitzsch, S. Hartmann, C. Schüll, L. Nuhn, B. Gerlitzki, E. Schmitt, H. Frey, H. Kunz, Chem. Eur. J. 2014, 15, 4232-4236.
(DOI: 10.1002/chem.201400256)