bis Semptember 2013
E-Mail: aochel@students.uni-mainz.de
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-2015- |
IF |
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66. |
Shanmugam, R., Fierer, J., Kaiser, S., Helm, M., Jurkowski, T. P., Jeltsch, A. (2015) Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences. Cell Discovery, Jun. 9, 1, 1501, epub ahead of print, Full text |
PMID: pending |
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N/A |
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65. |
Intermolecular 'cross-torque': the N4-cytosine propargyl residue is rotated to the 'CH'-edge as a result of Watson-Crick interaction. Domingo,O., Hellmuth, I., Jaeschke, A., Kreutz, C., Helm, M. (2015) Nuc Acids Res., Apr. 30, epub ahead of print, Full text |
PMID: 25934805 |
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8,4 |
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64. |
Hirsch, M. & Helm, M. (2015) Live cell imaging of duplex siRNA intracellular trafficking. Nuc Acids Res., Apr. 13, epub ahead of print, Full text |
PMID: 25870407 |
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8,4 |
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63. |
Rimbach, K., Kaiser, S., Helm, M., Dalpke, A.H., Eigenbrod, T. (2015). 2'-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells. J Innate Immun. Mar 20. Full text. |
PMID: 25823462 |
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4,6 |
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62. |
Juedes, A., Ebert, F., Baer, C., Thuering, K. L., Harrer, A., Klassen, R., Helm, M. & Schaffrath, R. (2015). Urmylation and tRNA thiolation functions of ubiquitin-like Uba4⢠Urm1 systems are conserved from yeast to man. FEBS letters. Mar 03. Full text. |
PMID: 25747390 |
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3,3 |
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61. |
Klassen, R., Grunewald, P., Thuering, K. L., Eichler, C., Helm, M., & Schaffrath, R. (2015). Loss of Anticodon Wobble Uridine Modifications Affects tRNALys Function and Protein Levels in Saccharomyces cerevisiae. PLoS ONE, Mar 6;10(3)., Full text. |
PMID: 25747122 |
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3,5 |
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60. |
Abdel-Fattah, W., Jablownski, D., Di Santo, R., Thuering, K.L., Scheidt, V., Hammermeister, A., Have, S. t., Helm, M., Schaffrath, R., Stark, M.J.R. (2015). ”Phosphorylation of Elp1 by Hrr25 Is Required for Elongator-Dependent tRNA Modification in Yeast.â Plos Gen. Jan 8. 11(1). Full text. |
PMID: 25569479 |
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8,2 |
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-2014- |
IF |
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59. |
Krieg, B., Hirsch, M., Scholz, E., Nuhn, L., Tabujew, I., Bauer, Hâ¦.,& Helm, M. (2014). ”New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes.â Pharm. Res. Oct 09. Full text. |
PMID: 25488263 |
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4,0 |
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58. |
Spenkuch, F., Hinze, G., Kellner, S., Kreutz, C., Micura, R., Basché, T. & Helm, M. (2014). ”Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor.â Nuc Acids Res.. Oct 09. Full text. |
PMID: 25300485 |
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8,3 |
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57. |
Kellner, S., Ochel, A., Thüring, K., Spenkuch, F., Neumann, J., Sharma, S., Entian, K.D., Schneider, D. & Helm, M. (2014). ”Absolute and relative quantification of RNA modifications via biosynthetic isotopomers.â Nuc Acids Res.. Aug 16. Epub ahead of print. |
PMID: 25129236 |
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8,3 |
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56. |
Blanco, S., Dietmann, S., Flores, J.V., Hussain, S., Kutter, C., Humphreys, P., Lukk, M., Lombard, P., Treps, L. Popis, M., Kellner, S., Hölter, S.M., Garret, L., Wurst, W., Becker, L., Klopstock, T., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., Karadottir, R.T., Helm, M., Ule, J., Gleeson, J.G., Odom, D.T., Frye, M. (2014). ”Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.â EMBO J., Jul 25. Epub ahead of print |
PMID: 25063673 |
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10,7 |
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55. |
Kaiser, S., Rimbach, K., Eigenbrod, T., Dalpke, A.H. & Helm, M. (2014). "A modified dinucleotide motif specifies tRNA recognition by TLR7." RNA Sep. 20(9):1351-5. |
PMID: 25051971 |
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5,9 |
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54. |
Fritz, T. Hirsch, M. Richter, F.C., Müller, S.S., Hofmann, A.M., Rusitzka, K.A., Markl, J., Massing, U., Frey, H. Helm, M. (2014). "Click modification of multifunctional liposomes bearing hyperbranched polyether chains." Biomacromolecules. (ACS Publications) Jul 14. 15(7):2440-8 |
PMID: 24805163 |
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5,4 |
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53. |
Kotaskova M., Osman Oglou O., Helm, M. (2014) "Synthesis of new asymmetric xanthene dyes via catalyst-free SNAr with sulfur nucleophiles" Org. Biomol Chem. Jun 21. 12(23):3816-20 |
PMID: 24802552 |
|
3,6 |
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52. |
Shanmugam, R., Aklujkar, M., Schäfer, M., Reinhardt, R., Nickel, O., Reuter, G., Lovley, D.R., Ehrenhofer-Murray, A., Nellen, W., Ankri, S., Helm, M. et al. (2014). "The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu." Nuc. Acids Res. (Oxford Univ Press) Apr 7. 42(10):6487-96. |
PMID: 24711368 |
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8,3 |
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51. |
Tabujew, I., Freidel, C., Krieg, B., Helm, M., Koynov, K., Müllen, K., Peneva, K. (2014). "The Guanidinium Group as a Key Part of Water-Soluble Polymer Carriers for siRNA Complexation and Protection against Degradation." Macromol. rapid comm. (Wiley Online Library) Apr 4. 35(13):1191-7. |
PMID: 24700561 |
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4,9 |
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50. |
Buchhaupt, M., Sharma,S., Kellner, S., Oswald, S.,Paetzold, M., Pfeifer, C., Watzinger, P., Schraeder, J., Helm, M., Entian, K.D.(2014). "Partial Methylation at Am100 in 18S rRNA of Baker's Yeast Reveals Ribosome Heterogeneity on the Level of Eukaryotic rRNA Modification." Plos One. (Public Library of Science), Feb 28 9(2):e89640. |
PMID: 24586927 |
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3,7 |
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49. |
Kellner, S., Neumann, J., Rosenkranz, D., Lebedeva, S., Ketting, R.F., Zischler, H., Schneider, D., & Helm, M.*(2014). "Profiling of RNA modifications by multiplexed stable isotope labelling." Chem. Commun. (Camb) 50(26), 3516-3518. |
PMID: 24567952 |
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6,4 |
|
-2013- |
IF |
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48. |
Kellner, S., Kollar, L. B., Ochel, A., Ghate, M. & Helm, M. (2013). "Structure-Function Relationship of Substituted Bromomethylcoumarins in Nucleoside Specificity of RNA Alkylation." Plos One. (Public Library of science) 8(7): e67945 doi:10.1371/journal.pone.0067945. |
PMID: 23844135 |
|
3,7 |
|
47. |
Machnicka, M. A., Milanowska, K., Osman Oglou, O., Purta, E., Kurkowska, M., Olchowik, A., Januszewski, W., Kalinowski, S., Dunin-Horkawicz, S., Rother, K. M., Helm, M., Bujnicki, J. M. & Grosjean, H. (2012). "MODOMICS: a database of RNA modification pathways--2012 update." Nucleic Acids Res. Oct 30. |
PMID: 23118484 |
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8,0 |
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-2012- |
IF |
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46. |
Seidu-Larry, S., Krieg, B., Hirsch, M., Helm, M. & Domingo, O. (2012). "A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge." Chem Commun. (Camb) 48(89): 11014-11016. |
PMID: 23037931 |
6,2 |
|
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45. |
Tuorto, F., Liebers, R., Musch, T., Schaefer, M., Hofmann, S., Kellner, S., Frye, M., Helm, M., Stoecklin, G. & Lyko, F. (2012). "RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis." Nat Struct Mol Biol. 19(9): 900-905. |
PMID: 22885326 |
12,7 |
|
|
44. |
Jurkowski, T. P., Shanmugam, R., Helm, M. & Jeltsch, A. (2012). "Mapping the tRNA Binding Site on the Surface of Human DNMT2 Methyltransferase." Biochemistry. 51(22): 4438-4444. |
PMID: 22591353 |
3,4 |
|
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43. |
Sencilo, A., Paulin, L., Kellner, S., Helm, M. & Roine, E. (2012). "Related haloarchaeal pleomorphic viruses contain different genome types." Nucleic Acids Res. 40(12): 5523-5534. |
PMID: 22396526 |
8,0 |
|
|
42. |
Nuhn, L., Hirsch, M., Krieg, B., Koynov, K., Fischer, K., Schmidt, M., Helm, M. & Zentel, R. (2012). "Cationic Nanohydrogel Particles as Potential siRNA Carriers for Cellular Delivery." ACS Nano. 6(3): 2198-2214. |
PMID: 22381078 |
9,9 |
|
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41. |
Gehrig, S., Eberle, M. E., Botschen, F., Rimbach, K., Eberle, F., Eigenbrod, T., Kaiser, S., Holmes, W. M., Erdmann, V. A., Sprinzl, M., Bec, G., Keith, G., Dalpke, A. H. & Helm, M. * (2012). "Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity." J Exp Med. 209(2): 225-233. |
PMID: 22312113 |
|
14,8 |
|
40. |
Hirsch, M., Strand, D. & Helm, M. * (2012). "Dye selection for live cell imaging of intact siRNA." Biol Chem. 393(1-2): 23-35. |
PMID: 22628296 |
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3,6 |
|
-2011- |
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39. |
Kobitski, A. Y., Hengesbach, M., Seidu-Larry, S., Dammertz, K., Chow, C. S., van Aerschot, A., Nienhaus, G. U.* & Helm, M.* (2011). "Single-Molecule FRET Reveals a Cooperative Effect of Two Methyl Group Modifications in the Folding of Human Mitochondrial tRNA(Lys)." Chem Biol 18(7): 928-936. |
PMID: 21802013 |
5,8 |
|
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38. |
Kellner, S., Seidu-Larry, S., Burhenne, J., Motorin, Y. & Helm, M.* (2011). "A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA." Nucleic Acids Res. 39(16): 7348-7360. |
PMID: 21646334 |
8,0 |
|
|
37. |
Nguyen, T. H., Steinbock, L. J., Butt, H. J., Helm, M.* & Berger, R.* (2011). "Measuring single small molecule binding via rupture forces of a split aptamer." J Am Chem Soc 133(7): 2025-2027. |
PMID: 21287983 |
9,0 |
|
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36. |
Dammertz, K., Hengesbach, M., Helm, M., Nienhaus, G. U. & Kobitski, A. Y. (2011). "Single-molecule FRET studies of counterion effects on the free energy landscape of human mitochondrial lysine tRNA." Biochemistry 50(15): 3107-3115. |
PMID: 21375355 |
3,4 |
|
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35. |
Motorin, Y., Burhenne, J., Teimer, R., Koynov, K., Willnow, S., Weinhold, E. & Helm, M.* (2011). "Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling." Nucleic Acids Res 39(5): 1943-1952. |
PMID: 21037259 |
8,0 |
|
|
-2010- |
||||
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34. |
Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M. & Lyko, F. (2010). "RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage." Genes Dev 24(15): 1590-1595. |
PMID: 20679393 |
12,8 |
|
|
33. |
Hengesbach, M., Voigts-Hoffmann, F., Hofmann, B. & Helm, M.* (2010). "Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET." RNA 16(3): 610-620. |
PMID: 20106954 |
5,9 |
|
|
32. |
Tovy, A., Siman Tov, R., Gaentzsch, R., Helm, M. & Ankri, S.* (2010). "A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity." PLoS Pathog 6(2): e1000775. |
PMID: 20174608 |
9,0 |
|
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-2009- |
||||
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31. |
Fuest, C., Bankstahl, M., Winter, P., Helm, M., Pekcec, A. & Potschka, H.* (2009). "In vivo down-regulation of mouse brain capillary P-glycoprotein: a preliminary investigation." Neurosci Lett 464(1): 47-51. |
PMID: 19679165 |
2,1 |
|
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30. |
Hayrapetyan, A., Grosjean, H. & Helm, M.* (2009). "Effect of a quaternary pentamine on RNA stabilization and enzymatic methylation." Biol Chem 390(9): 851-861. |
PMID: 19558320 |
3,6 |
|
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29. |
Hirsch, M., Ziroli, V., Helm, M. & Massing, U.* (2009). "Preparation of small amounts of sterile siRNA-liposomes with high entrapping efficiency by dual asymmetric centrifugation (DAC)." J Control Release 135(1): 80-88. |
PMID: 19124051 |
7,2 |
|
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-2008- |
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28. |
Jurkowski, T. P., Meusburger, M., Phalke, S., Helm, M., Nellen, W., Reuter, G. & Jeltsch, A.* (2008). "Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism." RNA 14(8): 1663-1670. |
PMID: 18567810 |
5,9 |
|
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27. |
Kobitski, A. Y., Hengesbach, M., Helm, M. & Nienhaus, G. U.* (2008). "Sculpting an RNA conformational energy landscape by a methyl group modification--a single-molecule FRET study." Angew Chem Int Ed Engl 47(23): 4326-4330. |
PMID: 18449867 |
12,7 |
|
|
26. |
Steinbock, L. J. & Helm, M.* (2008). "Wavelength dependence of photoinduced microcantilever bending in the UV-VIS range." Sensors 8(1): 23-34. |
1,8 |
||
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25. |
Hengesbach, M.**, Meusburger, M.**, Lyko, F. & Helm, M.* (2008). "Use of DNAzymes for site-specific analysis of ribonucleotide modifications." RNA 14(1): 180-187. |
PMID: 17998290 |
5,9 |
|
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-2007- |
||||
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24. |
Voigts-Hoffmann, F., Hengesbach, M., Kobitski, A. Y., van Aerschot, A., Herdewijn, P., Nienhaus, G. U. & Helm, M.* (2007). "A methyl group controls conformational equilibrium in human mitochondrial tRNA(Lys)." J Am Chem Soc 129(44): 13382-13383. |
PMID: 17941640 |
9,0 |
|
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23. |
Järve, A., Müller, J., Kim, I. H., Rohr, K., MacLean, C., Fricker, G., Massing, U., Eberle, F., Dalpke, A., Fischer, R., Trendelenburg, M. F. & Helm, M.* (2007). "Surveillance of siRNA integrity by FRET imaging." Nucleic Acids Res 35(18): e124. |
PMID: 17890733 |
8,0 |
|
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22. |
Wehrmeister, J., Fuss, A., Saurenbach, F., Berger, R. & Helm, M.* (2007). "Readout of micromechanical cantilever sensor arrays by Fabry-Perot interferometry." Rev Sci Instrum 78(10): 104105. |
PMID: 17979440 |
1,6 |
|
|
21. |
Kobitski, A. Y., Nierth, A., Helm, M., Jaschke, A. & Nienhaus, G. U.* (2007). "Mg2+-dependent folding of a Diels-Alderase ribozyme probed by single-molecule FRET analysis." Nucleic Acids Res 35(6): 2047-2059. |
PMID: 17344321 |
8,0 |
|
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-2006- |
||||
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20. |
Maniura-Weber, K**., Helm, M.**, Engemann, K., Eckertz, S., Mollers, M., Schauen, M., Hayrapetyan, A., von Kleist-Retzow, J. C., Lightowlers, R. N., Bindoff, L. A. & Wiesner, R. J.* (2006). "Molecular dysfunction associated with the human mitochondrial 3302A>G mutation in the MTTL1 (mt-tRNALeu(UUR)) gene." Nucleic Acids Res 34(22): 6404-6415. |
PMID: 17130166 |
8,0 |
|
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-2005- |
||||
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19. |
Möllers, M., Maniura-Weber, K., Kiseljakovic, E., Bust, M., Hayrapetyan, A., Jaksch, M., Helm, M., Wiesner, R. J.* & von Kleist-Retzow, J. C. (2005). "A new mechanism for mtDNA pathogenesis: impairment of post-transcriptional maturation leads to severe depletion of mitochondrial tRNASer(UCN) caused by T7512C and G7497A point mutations." Nucleic Acids Res 33(17): 5647-5658. |
PMID: 16199753 |
8,0 |
|
|
18. |
Kurschat, W. C., Müller, J., Wombacher, R. & Helm, M.* (2005). "Optimizing splinted ligation of highly structured small RNAs." RNA 11(12): 1909-1914. |
PMID: 16251384 |
5,9 |
|
|
17. |
Helm, M., Petermeier, M., Ge, B., Fiammengo, R. & Jäschke, A.* (2005). "Allosterically activated Diels-Alder catalysis by a ribozyme." J Am Chem Soc 127(30): 10492-10493. |
PMID: 16045328 |
9,0 |
|
|
16. |
Helm, M., Servant, J. J., Saurenbach, F. & Berger, R.* (2005). "Read-out of micromechanical cantilever sensors by phase shifting interferometry." Applied Physics Letters 87(6). |
3,8 |
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-2004- |
||||
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15. |
Sissler, M., Helm, M., Frugier, M., Giege, R. & Florentz, C.* (2004). "Aminoacylation properties of pathology-related human mitochondrial tRNA(Lys) variants." RNA 10(5): 841-853. |
PMID: 15100439 |
5,9 |
|
|
14. |
Helm, M. & Attardi, G.* (2004). "Nuclear control of cloverleaf structure of human mitochondrial tRNA(Lys)." J Mol Biol 337(3): 545-560. |
PMID: 15019776 |
4,0 |
|
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13. |
Asin-Cayuela, J., Helm, M. & Attardi, G.* (2004). "A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity." J Biol Chem 279(15): 15670-15677. |
PMID: 14744862 |
5,3 |
|
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-2001- |
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12. |
Schiffer, S., Helm, M., Theobald-Dietrich, A., Giege, R. & Marchfelder, A.* (2001). "The plant tRNA 3' processing enzyme has a broad substrate spectrum." Biochemistry 40(28): 8264-8272. |
PMID: 11444972 |
3,4 |
|
|
11. |
Helm, M.*, Kopka, M. L., Sharma, S. K., Lown, J. W. & Giege, R. (2001). "RNase activity of a DNA minor groove binder with a minimalist catalytic motif from RNase A." Biochem Biophys Res Commun 281(5): 1283-1290. |
PMID: 11243875 |
2,6 |
|
|
-2000- |
||||
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10. |
Helm, M., Brule, H., Friede, D., Giege, R., Putz, D. & Florentz, C.* (2000). "Search for characteristic structural features of mammalian mitochondrial tRNAs." RNA 6(10): 1356-1379. |
PMID: 11073213 |
5,9 |
|
|
-1999- |
||||
|
9. |
Helm, M., Giege, R. & Florentz, C.* (1999). "A Watson-Crick base-pair-disrupting methyl group (m1A9) is sufficient for cloverleaf folding of human mitochondrial tRNALys." Biochemistry 38(40): 13338-13346. |
PMID: 10529209 |
3,4 |
|
|
8. |
Vlasov, A. V., Helm, M., Naumov, V. A., Breusov, A. A., Buneva, V. N., Florentz, C., Giege, R. & Nevinskii, G. A.* (1999). "[Features of tRNA hydrolysis by autoantibodies from blood serum of patients with certain autoimmune and virus diseases]." Mol Biol (Mosk) 33(5): 866-872. |
PMID: 10579192 |
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7. |
Vlassov, A. V., Helm, M., Florentz, C., Naumov, V. A., Breusov, A. A., Buneva, V. N., Giege, R. & Nevinsky, G. A.* (1999). "Variability of Substrate Specificity of Serum Antibodies Obtained from Patients with Different Autoimmune and Viral Diseases in Reaction of tRNA Hydrolysis." Russ J Immunol 4(1): 25-32. |
PMID: 12687113 |
||
|
6. |
Helm, M., Brule, H., Giege, R. & Florentz, C.* (1999). "More mistakes by T7 RNA polymerase at the 5' ends of in vitro-transcribed RNAs." RNA 5(5): 618-621. |
PMID: 10334331 |
5,9 |
|
|
5. |
Helm, M., Florentz, C.*, Chomyn, A. & Attardi, G. (1999). "Search for differences in post-transcriptional modification patterns of mitochondrial DNA-encoded wild-type and mutant human tRNALys and tRNALeu(UUR)." Nucleic Acids Res 27(3): 756-763. |
PMID: 9889270 |
8,0 |
|
|
-1998- |
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4. |
Degoul, F., Brule, H., Cepanec, C., Helm, M., Marsac, C., Leroux, J., Giege, R. & Florentz, C.* (1998). "Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene." Hum Mol Genet 7(3): 347-354. |
PMID: 9466989 |
8,1 |
|
|
3. |
Vlassov, A., Florentz, C., Helm, M., Naumov, V., Buneva, V., Nevinsky, G. & Giege, R.* (1998). "Characterization and selectivity of catalytic antibodies from human serum with RNase activity." Nucleic Acids Res 26(23): 5243-5250. |
PMID: 9826744 |
8,0 |
|
|
2. |
Frugier, M., Helm, M., Felden, B., Giege, R. & Florentz, C. (1998). "Sequences outside recognition sets are not neutral for tRNA aminoacylation. Evidence for nonpermissive combinations of nucleotides in the acceptor stem of yeast tRNAPhe." J Biol Chem 273(19): 11605-11610. |
PMID: 9565578 |
5,3 |
|
|
1. |
Helm, M., Brule, H., Degoul, F., Cepanec, C., Leroux, J. P., Giege, R. & Florentz, C.* (1998). "The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA." Nucleic Acids Res 26(7): 1636-1643. |
PMID: 9512533 |
8,0 |
|