Selected Publications

Huang C, Sakry D, Menzel L, Dangel L, Sebastiani A, Krämer T, Karram K, Engelhard K, Trotter J, Schäfer MK. Lack of NG2 exacerbates neurological outcome and modulates glial responses after traumatic brain injury. Glia. 2016 Apr;64(4):507-23. doi: 10.1002/glia.22944. Epub 2015 Dec 6.

Maus F, Sakry D, Binamé F, Karram K, Rajalingam K, Watts C, Heywood R, Krüger R, Stegmüller J, Werner HB, Nave KA, Krämer-Albers EM, Trotter J. The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2. PLoS One. 2015 Sep 4;10(9):e0137311. doi: 10.1371/journal.pone.0137311. eCollection 2015.

Sakry D, Trotter J. The role of the NG2 proteoglycan in OPC and CNS network function. Brain Res. 2015 Jun 19. pii: S0006-8993(15)00472-2. doi: 10.1016/j.brainres.2015.06.003.

Sakry D, Yigit H, Dimou L, Trotter J. Oligodendrocyte precursor cells synthesize neuromodulatory factors. PLoS One. 2015 May 12;10(5):e0127222. doi: 10.1371/journal.pone.0127222. eCollection 2015.

Sakry D*, Neitz A*, Singh J, Frischknecht R, Marongiu D, Binamé F, Perera SS, Endres K, Lutz B, Radyushkin K, Trotter J**, Mittmann T**. Oligodendrocyte Precursor Cells Modulate the Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2. PLoS Biol. 2014 Nov 11;12(11):e1001993. doi: 10.1371/journal.pbio.1001993. eCollection 2014. * and ** equal contribution.

Passlick S, Trotter J, Seifert G, Steinhäuser C, Jabs R.The NG2 Protein Is Not Required for Glutamatergic Neuron-NG2 Cell Synaptic Signaling. Cereb Cortex. 2014 Aug 6. pii: bhu171.

Gonsior C, Binamé F, Frühbeis C, Bauer NM, Hoch-Kraft P, Luhmann HJ, Trotter J, White R. Oligodendroglial p130Cas is a target of Fyn kinase involved in process formation, cell migration and survival.
PLoS One. 2014 Feb 21;9(2):e89423. doi: 10.1371/journal.pone.0089423. eCollection 2014.

Huang W, Zhao N, Bai X, Karram K, Trotter J, Goebbels S, Scheller A, Kirchhoff F. Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development. Glia. 2014 Jun;62(6):896-913. doi: 10.1002/glia.22648. Epub 2014 Feb 28.

Rajendran L, Bali J, Barr MM, Court FA, Krämer-Albers EM, Picou F, Raposo G, van der Vos KE, van Niel G, Wang J, Breakefield XO. Emerging roles of extracellular vesicles in the nervous system.J Neurosci. 2014 Nov 12;34(46):15482-9. doi: 10.1523/JNEUROSCI.3258-14.2014.

Fröhlich D, Kuo WP, Frühbeis C, Sun JJ, Zehendner CM, Luhmann HJ, Pinto S, Toedling J, Trotter J, Krämer-Albers EM. Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26;369(1652). pii: 20130510. doi: 10.1098/rstb.2013.0510.

White R, Krämer-Albers EM.Axon-glia interaction and membrane traffic in myelin formation.Front Cell Neurosci. 2014 Jan 6;7:284. doi: 10.3389/fncel.2013.00284. eCollection 2014.

Frühbeis C, Fröhlich D, Kuo WP, Krämer-Albers EM.Front Cell Neurosci. 2013 Oct 30;7:182. doi: 10.3389/fncel.2013.00182.Front Cell Neurosci. 2013 Oct 30;7:182. doi: 10.3389/fncel.2013.00182.

Frühbeis C*, Fröhlich D*, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers EM. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. 2013 Jul;11(7):e1001604. doi: 10.1371/journal.pbio.1001604. Epub 2013 Jul 9. * equal contribution

Binamé F, Sakry D, Dimou L, Jolivel V, Trotter J. NG2 Regulates Directional Migration of Oligodendrocyte Precursor Cells via Rho GTPases and Polarity Complex Proteins. J Neurosci. 2013 Jun 26;33(26):10858-74. doi: 10.1523/JNEUROSCI.5010-12.2013.

Frühbeis C, Fröhlich D, Krämer-Albers EM. Emerging roles of exosomes in neuron-glia communication.Front Physiol. 2012;3:119. Epub 2012 Apr 30.

White R*, Gonsior C*, Bauer NM, Krämer-Albers EM, Luhmann HJ, Trotter J. Heterogeneous nuclear ribonucleoprotein (hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myelin basic protein (MBP) synthesis. J Biol Chem. 2012 Jan 13;287(3):1742-54. * equal contribution

Sakry D, Karram K, Trotter J. Synapses between NG2 glia and neurons. J Anat. 2011 Jul;219(1):2-7. Review

Feldmann A, Amphornrat J, Schönherr M, Winterstein C, Möbius W, Ruhwedel T, Danglot L, Nave KA, Galli T, Bruns D, Trotter J, and Krämer-Albers EM. Transport of the Major Myelin Protein PLP is Directed by the R-SNAREs VAMP3 and VAMP7. J. Neurosci., 2011 Apr 13;31(15):5659-72.

Krämer-Albers EM and White R (2011) From axon-glial signalling to myelination: The integrating role of oligodendroglial Fyn Kinase. Cell Mol Life Sci. 2011 Jun;68(12):2003-12. Review.

Maglione M, Tress O, Haas B, Karram K, Trotter J, Willecke K, Kettenmann H. (2010) Oligodendrocytes in mouse corpus callosum are coupled via gap junction channels formed by connexin47 and connexin 32. Glia 58(9):1104-17.

Trotter J., Karram K., Nishiyama A. (2010) NG2 cells: properties, progeny and origin. Brain Research Reviews, 63(1-2):72-82.

Feldmann A, Winterstein C, White R, Trotter J, Krämer-Albers EM. (2009)
Comprehensive analysis of expression, subcellular localization, and cognate pairing of SNARE proteins in oligodendrocytes.
J Neurosci Res. 2009 Jun;87(8):1760-72.

Karram K., Goebbels S.
, Schwab M., Jennissen K., Seifert G., Steinhauser C., Nave KA. and Trotter J. (2008)
NG2-expressing cells in the nervous system revealed by the NG2-EYFP-knockin mouse.
Genesis 46:743-757.

White R., Gonsior C., Krämer-Albers E., Stöhr N., Hüttelmaier S., and Trotter J. (2008)
Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2-dependent RNA granules.
J. Cell Biol., 181 (4), 579-586.

Chatterje, N.*, Stegmüller J.*, Schätzle P., Karram K., Koroll M., Werner H., Nave K-A., and Trotter J. (2008)
Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells.
J Biol Chem. 283(13):8310-7. *joint first authors.

Winterstein, C., Trotter, J., Krämer-Albers, E.M. (2008)
Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling.
Journal of Cell Science 121 (6), 834-842.

Simons, M. and Trotter, J. (2007)
Wrapping it up: the Cell Biology of Myelination.
Curr. Opin. Neurobiol.17(5):533-40.

Krämer-Albers EM, Bretz N, Tenzer S, Winterstein C, Möbius W, Berger H, Nave KA, Schild H and Trotter J (2007) Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons? Proteomics Clin. Appl. 11, 1446-1461.

Kramer-Albers, E-M., Gehrig-Burger, K., Thiele. C., Trotter, J., Nave, K.-A. (2006)
Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia.
J. Neurosci. 26(45):11743-52.

Karram, K., Chatterjee, N. and Trotter, J. (2005)
NG2-expressing cells in the nervous system: role of the proteoglycan in migration and glia-neuron interaction.
J. Anat. 207: 735-744.

Trotter, J. (2005)
NG2-positive cells in CNS function and the pathological role of antibodies against NG2 in demyelinating disease.
J. Neurol. Sci., 233:37-42.

Krämer, E.M. and Trotter J. (2004)
Axon-Glia Interaktion und Myelinisierung – oder wie ein erster Kuss in Umhüllung resultiert.
Neuroforum, 4.04, 268-275.

Stegmüller J., Werner, H., Nave, K-A., Trotter J. (2003)
The proteoglycan NG2 is complexed with AMPA receptors by the PDZ protein GRIP in glial progenitor cells: implications for glial-neuronal signalling.
J. Biol. Chem. 278: 3590-3598.

Stegmüller J., Schneider S.S., Hellwig A., Garwood J.G., Trotter J. (2002)
AN2, the mouse homologue of NG2, is a surface antigen on glial precursor cells implicated in control of cell migration.
J. Neurocytology, special issue on NG2, invited review, 31: 497-505.

Simons, M., Kramer, E.M., Macchi, P., Rathke-Hartlieb, S., Trotter, J., Nave, K-A., Schulz, J.B. (2002)
Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease.
J. Cell Biol., 157: 327-36.

Klein, C., Krämer, E-M., Marie-Cardine, A., Schraven, B., Brandt, R., and Trotter, J. (2002)
Process outgrowth of oligodendrocytes is promoted by interaction of Fyn kinase with the cytoskeletal protein Tau.
J. Neurosci., 22: 698-707.

Diers-Fenger, M., Kirchhoff, F., Kettenmann, H. Levine, J.M. and Trotter, J. (2001)
AN2/NG2 protein-expressing glial progenitor cells in the murine CNS: isolation, differentiation and association with radial glia.
Glia, 34: 213-228.

Schneider, S.S., Niehaus, A., Bosse, F., D`Urso, D., Müller, H-W., Sereda, M., Nave, K-A., Niehaus, A., and Trotter, J. (2001)
The AN2 protein is a novel marker for the Schwann cell lineage expressed by immature and non-myelinating Schwann cells.
J.Neurosci., 21:920-933.

Simons, M., Krämer, E-M., Thiele, C., Stoffel, W., and Trotter, J. (2000)
Assembly of myelin by association of Proteolipid Protein with cholesterol- and galactosylceramide-rich membrane domains.
J. Cell Biol., 151, 143-154.

Niehaus, A., Shi, J., Grzenkowski, M. Diers-Fenger, M., Archelos, J., Hartung, H.-P., Toyka, K., Brück, W. and Trotter, J. (2000)
Patients with active relapsing-remitting Multiple Sclerosis synthesise antibodies recognising oligodendrocyte progenitor cell-surface protein: implications for remyelination.
Annals Neurol. 48, 362-371.

Krämer, E-M., Klein, C., Koch, T., Boytinck, M. and Trotter, J. (1999)
Compartmentation of fyn kinase with glycosyl-phosphatidyl inositol-anchored molecules in oligodendrocytes facilitates kinase activation during myelination.
J.Biol. Chem. 274, 29042-29049.

Niehaus, A., Stegmüller, J., Diers-Fenger, M. and Trotter, J. (1999)
Cell-surface glycoprotein of oligodendrocyte progenitors involved in migration.
J. Neurosci. 19, 4948-4961.

Krämer, E., Koch, T., Niehaus, A. and Trotter, J. (1997)
Oligodendrocytes direct glycosyl phosphatidylinositol-anchored proteins to the myelin sheath in glycosphingolipid-rich complexes.
J. Biol. Chem. 272, 8937-8945.

Koch, T., Brugger, T., Bach, A., Gennarini, G. and Trotter, J. (1997)
Expression of the Immunoglobulin Superfamily cell adhesion molecule F3 by oligodendrocyte-lineage cells.
Glia 19, 199-212.

Jung, M., Krämer, E., Grzenkowski, M., Aguzzi, A., Khazaie, K., Tang, K., Blakemore, W., Blankenfeld, G., Kettenmann, H. and Trotter, J. (1995)
Lines of murine oligodendrocyte precursor cells immortalised via an activated neu tyrosine kinase show distinct degrees of interaction with axons in vitro and in vivo.
Eur. J. Neurosci. 7, 1245-1265.