Benjamin Weber

Research Interest

  • Investigation on Polyplexes from pDNA and polypept(o)ide Triblock-copolymers


  • B. Weber, A. Birke, K. Fischer, M. Schmidt, M. Barz
    Solution Properties of Polysarcosine: From Absolute and Relative Molar Mass Determinations to Complement Activation
    Macromolecules 2018, doi: 10.1021/acs.macromol.8b00258

  • B. Weber, C. Kappel, M. Scherer, M. Helm, M. Bros, S. Grabbe, M. Barz
    PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept(o)ide-Based Polymersomes
    Macromol. Biosci. 2017, 1700061.

  • K. Sato, W. Ji, L. C. Palmer, B. Weber, M. Barz, S. I. Stupp
    Programmable Assembly of Peptide Amphiphile via Noncovalent-to-Covalent Bond Conversion
    Journal of the American Chemical Society 2017 139 (26): 8995-9000. doi: 10.1021/jacs.7b03878

  • P. Heller, D. Hobernik, U. Lächelt, M. Schinnerer, B. Weber, M. Schmidt, E. Wagner, M. Bros, M. Barz
    Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines
    Journal of Controlled Release, Volume 258 2017, 258: 146-160.

  • P. Heller, J. Zhou, B. Weber, D. Hobernik, M. Bros, F. Schmid, M. Barz
    The Influence of Block Ionomer Microstructure on Polyplex Properties: Can Simulations Help to Understand Differences in Transfection Efficiency?
    Small 2017, 13: 1603694.

  • R. Holm, B. Weber, P. Heller, K. Klinker, D. Westmeier, D. Docter, R. H. Stauber, M. Barz
    Synthesis and Characterization of Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars
    Macromol. Biosci. 2017, 17: 1600514.

  • Hu, Q.; Rijcken, C.; van Gaal, E.; Brundel, P.; Kostkova, H.; Etrych, T.; Weber, B.; Barz, M.; Kiessling, F.; Prakash, J.; Storm, G.; Hennink, W.; Lammers, T.
    Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications.
    Journal of Controlled Release 2016, online since 9 July 2016, ISSN 0168-3659

  • Weber, B.; Seidl, C.; Schwiertz, D.; Scherer, M.; Bleher, S.; Süss, S.; Barz, M.
    Polysarcosine-Based Lipids: From Lipopolypeptoid Micelles to Stealth-Like Lipids in Langmuir Blodgett Monolayers.
    Polymers 2016, 8: 427. doi:10.3390/polym8120427

  • Heller, P.; Weber, B.; Birke, A.; Barz, M.
    Synthesis and Sequential Deprotection of Triblock Copolypept(o)ides Using Orthogonal Protective Group Chemistry​
    Macromol. Rapid Commun. 2015 36: 38-44. doi: 10.1002/marc.20140046

  • Heller, P.; Mohr, N.; Birke, A.; Weber, B.; Reske-Kunz, A.; Bros, M.; Barz, M.
    Directed Interactions of Block Copolypept(o)ides with Mannose-binding Receptors: PeptoMicelles Targeted to Cells of the Innate Immune System.
    Macromol. Biosci. 2015, 15: 63–73. doi: 10.1002/mabi.201400417

  • Huesmann, D.; Sevenich, A.; Weber, B.; Barz, M.
    A head-to-head comparison of poly(sarcosine) and poly(ethylene glycol) in peptidic, amphiphilic block copolymers.
    Polymer 2015, 67: 240–248.

  • Holm, R.; Klinker, K.; Weber, B.; Barz, M.
    Synthesis of Amphiphilic Block Copolypept(o)ides by Bifunctional Initiators: Making PeptoMicelles Redox Sensitive.
    Macromol. Rapid Commun. 2015, 36: 2083–2091. doi:10.1002/marc.201500402

  • Heller, P.; Birke, A.; Huesmann, D.; Weber, B.; Fischer, K.; Reske-Kunz, A.; Bros, M.; Barz, M.
    Introducing PeptoPlexes: Polylysine-block-Polysarcosine Based Polyplexes for Transfection of HEK 293T Cells.
    Macromol. Biosci. 2014 14: 1380–1395. doi: 10.1002/mabi.201400167

  • John B. Matson, Matthew J. Webber, Vibha K. Tamboli, Benjamin Weber and Samuel I. Stupp
    A peptide-based material for therapeutic carbon monoxide delivery
    Soft Matter 2012,8: 6689-6692.


Johannes Gutenberg-Universität Mainz
Institut für Organische Chemie
Duesbergweg 10-14
D-55099 Mainz

Tel: (+49-6131) 39-25467
Fax: (+49-6131) 39-24778

Mail to Benjamin