pubmed (for full texts), go here to see our databank depositions

(undergraduate student authors in italics)


(44) Zengerling, L., Kemper. B., Hellmich, U.A., Besenius, P. (2020)Synthesis and Structural Stability of α-Helical Au(I)-Metallopeptides. Synlett, accepted

(43) Wesenberg, L., Diehl, E., Zähringer, T.B., Dörr, C., Schollmeyer, D., Shimizu, A., Yoshida, J., Hellmich, U.A., Waldvogel, S.R. (2020) Metal-free Twofold Electrochemical C-H Amination of Activated Arenes: Application to Medicinally Relevant Precursor Syntheses.Chemistry – A European Journal, accepted

(42) Jungglas, B., Orru, R., Axt, A., Siebenaller, C., Steinchen, W., Heidrich, J., Hellmich, U.A., Hellmann, N., Wolf, E., Weber, S.L., Schneider, D. (2020) IM30 IDPs form a membrane protective carpet upon super-complex disassembly. Commun. Biol., accepted

(41) Ford#, R.C, Hellmich#, U.A. (2020) What monomeric nucleotide binding domains can teach us about dimeric ABC proteins. FEBS Lett., accepted (#corresponding authors)

(40) Maiorana,S., Ettari R., Previti, S., Amendola, G., Wagner, A., Cosconati, S., Hellmich, U.A., Schirmeister, T., Zappalà, M. (2020) Peptidyl vinyl ketone irreversible inhibitors of rhodesain: modifications of the P2 fragment. ChemMedChem, accepted .

(39) Dietschreit, J.C.B., Wagner, A., Le, T.A., Klein, P., Schindelin, H., Opatz, T., Engels, B., Hellmich#, U.A., Ochsenfeld#, C. (2020) Predicting 19F NMR Chemical Shifts: A Combined Computational and Experimental Study of a Trypanosomal Oxidoreductase-Inhibitor Complex. Angew. Chem. Int. Ed. Engl., accepted DOI: 10.1002/anie.202000539 (#corresponding authors)

(38) Klein, P., Barthels, F., Johé, P., Wagner, A., Tenzer, S., Distler, U., Le, T.A., Schmid, P., Engel, V., Engels, B., Hellmich, U.A., Opatz, T., Schirmeister, T.  (2020) Naphthoquinones as inhibitors of cysteine proteases. Molecules,25(9):2064. doi: 

(37) Klein, P., Johé, P., Wagner, A., Jung, S., Kühlborn, J., Tenzer, S., Distler, U., Waigel, W., Engels, B., Hellmich, U.A., Opatz, T., Schirmeister, T. (2020) New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and unexpected Prodrug Identification. Molecules, 25(6), 1451; doi: 10.3390/molecules25061451

(36) Goretzki, B., Heiby, J., Hacker, C. Neuweiler, H., Hellmich, U.A. (2020) NMR assignments of a dynamically perturbed and dimerization inhibited N-terminal domain variant of a spider silk protein from E. australis. Biomol NMR Assign. 14:67–71. doi: 10.1007/s12104-019-09922-w.

(35) Steiert, E., Ewald, J., Wagner, A., Hellmich, U.A., Frey, H., Wich, P.R. (2020) pH-Responsive Protein Nanoparticles via Conjugation of Degradable PEG to the Surface of Cytochrome c. Polymer Chemistry, 11, 551-559.

FEBS Letters Special Edition "Diversity of Structure and Function of ABC Transporters", Guest Editors: Ute A. Hellmich, Karl Kuchler, Amro Hamdoun, Gergely Szakacs


(34) Millies, B., von Hammerstein, F., Gellert, A., Hammerschmidt, S., Barthels, F., Göppel, U., Immerheiser, M., Elgner, F., Jung, N., Basic, M., Kersten, C., Kiefer, W., Bodem, J., Hildt, E., Windbergs, M., Hellmich#, U.A., Schirmeister#, T. (2019) Proline-based allosteric inhibitors of Zika and Dengue virus NS2B/NS3 proteases. J. Med. Chem. 62(24):11359-11382. (#corresponding authors)

(33) Ettari, R., Previti, S., Maiorana, S., Amendola, G., Wagner, A., Cosconati, S., Schirmeister, T., Hellmich, U.A., Zappalà, M. (2019) Optimization strategy of novel peptide-based Michael acceptors for the treatment of Human African Trypanosomiasis. J. Med. Chem. 62(23):10617-10629.

(32) Heiby*, J., Goretzki*, B., Johnson, C., Hellmich#, U.A., Neuweiler#, H. (2019) Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silk. Nature Commun. 10(1):4378.  doi: 10.1038/s41467-019-12365-5. (*shared first authors, #corresponding authors)

(31) von Hammerstein, F., Lauth, L. M., Hammerschmidt, S., Wagner, A., Schirmeister, T., Hellmich, U.A. (2019) Cis autocatalytic cleavage of glycine‐linked Zika virus NS2B‐NS3 protease constructs. FEBS Lett. 593(16):2204-2213. doi: 10.1002/1873-3468.13507.

(30) Viet, K.K., Wagner, A., Schwickert, K., Hellwig, N., Brennich, M., Bader, N., Schirmeister, T., Morgner, N., Schindelin, H., Hellmich, U.A. (2019) Structure of the human TRPML2 ion channel extracytosolic/lumenal domain. Structure, 27(8):1246-1257.

(29) Rose-Sperling, D., Tran, M. A., Lauth, L.M., Goretzki, B., Hellmich, U.A. (2019) 19F NMR as a versatile tool to study membrane protein structure and dynamics. Biol. Chem., 400(10):1277-1288.

(28b) Wagner, A., Le, T.A., Brennich, M., Klein, P., Bader, N., Diehl, E., Paszek, D., Weickhmann, A.K., Dirdjaja, N., Krauth-Siegel, R.L., Engels, B., Opatz, T., Schindelin, H., Hellmich, U.A. (2019) Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes. Angewandte Chemie Int. Ed. 58(11):3640-3644. Angew. Chem. Int. Ed. 10.1002/anie.201810470

(28a) Wagner, A., Le, T. A., Brennich, M., Klein, P., Bader, N., Diehl, E., Paszek, D., Weickhmann, A. K., Dirdjaja, N., Krauth-Siegel, R. L., Engels, B., Opatz, T., Schindelin, H., Hellmich, U.A. (2019)  Inhibitor-induzierte Dimerisierung einer essentiellen Oxidoreduktase aus Afrikanischen Trypanosomen. Angewandte Chemie, 131(11):3679-3683.


(27) Goretzki, B., Glogowski, N.A., Diehl, E., Duchardt-Ferner, E., Hacker, C., Gaudet, R., Hellmich, U. A. (2018) Structural basis of TRPV4 N-terminus interaction with Syndapin/PACSIN1-3 and PIP2. Structure, 26(12):1583-1593.

(26) Howard#, R.J., Carnevale#, V., Delemotte#, L., Hellmich#, U. A., Rothberg#, B. (2018) Permeating disciplines: overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport. Biochim. Biophys. Acta Biomembr. 1860(4):927-942. Front Cover. (#corresponding authors)

(25) Szöllösi, D., Rose-Sperling, D, Hellmich, U. A., Stockner, T. (2018) Comparison of mechanistic transport cycle models of ABC exporters. Biochim. Biophys. Acta Biomembr. 1860(4):818-832.

(24) Hellmich#, U.A., McILwain#, B., Doshi#, R. (2018) Where do we go from here? Membrane protein research beyond the structure-function horizon. Editorial: Biochim. Biophys. Acta Biomembr. 1860(4):801-803. (#corresponding authors)

BBA Biomembranes Special Edition "Beyond the Structure-Function Horizon of Membrane Proteins", Guest Editors: Ute A. Hellmich, Rukap Doshi, Benjamin McIlwain


(23) Preveti S, Ettari R, Cosconati S, Amendola G, Chouchene K, Wagner A, Hellmich UA, Ulrich K, Krauth-Siegel RL, Wich PR, Schmid I, Schirmeister T, Gut J, Rosenthal PJ, Grasso S, Zappalà M. (2017) Development of novel peptide-based Michael acceptors targeting rhodesain and falcipain-2 for the treatment of Neglected Tropical Diseases (NTDs). J. Med. Chem. 60(16):6911-6923.

(22) Wagner, A., Diehl, E., Krauth-Siegel, R.L., Hellmich, U. A. (2017) Backbone NMR assignments of tryparedoxin, the central protein in the hydroperoxide detoxification cascade of African trypanosomes, in the oxidized and reduced form. Biomol. NMR Assign. 11(2):193-196.

(21) Neumann, J., Rose-Sperling, D. and Hellmich, U. A. (2017) Diverse relations between lipids and ABC transporters: an overview. Biochim. Biophys. Acta Biomembr.  1859(4):605-618.


(20) Latorre, A., Schirmeister, T., Kesselring, J., Jung, S., Johé, P., Hellmich, U. A., Heilos, A., Engels, B., Krauth-Siegel, R. L., Dirdjaja, N., Bou-Iserte, L., Rodríguez, S., González, F. V. (2016) Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain. ACS Med. Chem. Lett. 7(12):1073-1076.

(19) Schirmeister, T., Kesselring, J., Jung, S., Schneider, T., Weickert, A., Becker, J., Lee, W., Bamberger, D., Wich, P. R., Distler, U., Tenzer, S., Johe, P., Hellmich, U. A., Engels, B. (2016) Quantum chemical-based Protocol for the rational Design of covalent Inhibitors. J. Am. Chem. Soc., 138(27):8332-5.


(18) Hellmich#, U.A., Mönkemeyer L, Velamakanni S, van Veen HW, Glaubitz# C. (2015) Effects of nucleotide binding to LmrA: A combined MAS-NMR and solution NMR study. Biochim. Biophys. Acta Biomembr. 1848(12):3158-65. (#corresponding authors)

(17) Hacker, C., Christ, N. A., Duchardt-Ferner,E., Korn, S., Göbl, C., Berninger, L., Düsterhus, S., Hellmich, U. A., Madl, T., Kötter, P., Entian, K., Wöhnert, J. (2015) The solution structure of the lantibiotic immunity protein NisI and its interactions with nisin. J. Biol. Chem. 290(48):28869-86.

Publications before 2015:

(16) Hellmich#, U.A. and Gaudet#, R. (2014) High-resolution views of TRPV1 and their implications for the TRP channel superfamily. In Mammalian Transient Receptor Potential (TRP) cation channels, B. Nilius, and V. Flockerzi, eds. (Heidelberg, Germany: Springer DE). Handb. Exp. Pharmacol. 223:991-1004.  (#corresponding authors)

(15) Hellmich#, U.A. and Gaudet#, R. (2014) Structural Biology of TRP Channels. In Mammalian Transient Receptor Potential (TRP) cation channels, B. Nilius, and V. Flockerzi, eds. (Heidelberg, Germany: Springer DE). Handb. Exp. Pharmacol. 223:963-90. (#corresponding authors)

(14) Hellmich, U.A., Weis, B.L., Luitikov, A., Wurm, J.P., Christ, N.A., Hantke, K., Kötter, P., Entian, K.D., Schleiff, E. and Wöhnert, J. (2013) Essential ribosome assembly factor Fap7 regulates a hierarchy of RNA-protein interactions during small ribosomal subunit biogenesis. Proc. Nat. Acad. Sci. USA 110(38):15253-8.

(13) Garcia-Elias, A., Mrkonjic, S., Pardo-Pastor, C., Inada, H., Hellmich, U.A., Rubio-Moscardo, F., Plata, C., Gaudet, R., Vicente, R. and Valverde, M.A. (2013) PIP2-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli. Proc. Nat. Acad. Sci. USA 110(23):9553-8.

(12) Mörs, K., Hellmich, U.A., Basting, D., Marchand, P., Wurm, J.P., Haase, W. and Glaubitz, C. (2013) A lipid-dependent link between activity and oligomerization state of the M. tuberculosis SMR protein Tbsmr. Biochim. Biophys. Acta Biomembr. 1828(2):561-7.

(11) Hellmich, U.A. and Wöhnert, J. (2013) Backbone resonance assignments for a homolog of the essential ribosome biogenesis factor Fap7 from P. horikoshii in its nucleotide-free and -bound forms. Biomol. NMR Assign. 7(2):261-5.

(10) Christ, N.A., Bochmann, S., Gottstein, D., Duchardt-Ferner, E., Hellmich, U.A., Düsterhus, S., Kötter, P., Güntert, P., Entian, K.D. and Wöhnert, J. (2012) The first structure of a LanI protein, SpaI: The protein conferring autoimmunity against the lantibiotic subtilin in Bacillus subtilis reveals a novel fold.  J. Biol. Chem. 287(42):35286-98.

(9) Hellmich*, U.A., Lyubenova*, S., Kaltenborn, E., Doshi, R., van Veen, H. W., Prisner, T.F. and Glaubitz, C. (2012) Probing the ATP hydrolysis cycle of the ABC multidrug transporter LmrA by pulsed EPR Spectroscopy. J. Am. Chem. Soc., 134(13):5857-62.(*contributed equally)

(8) Hellmich, U.A., Duchardt-Ferner, E., Glaubitz, C. and Wöhnert, J. (2012) Backbone NMR resonance assignments of the nucleotide binding domain of the ABC multidrug transporter LmrA from Lactococcus lactis in its ADP-bound state. Biomol. NMR Assign. 6(1):69-73.

(7) Ullrich*, S.J., Hellmich*, U.A., Ullrich, S. and Glaubitz, C. (2011) Interfacial enzyme kinetics of a membrane bound kinase analyzed by real-time MAS-NMR. Nature Chem. Biol. 7(5):263-70. (*contributed equally)

(6) Zutz, A., Hoffman, J., Hellmich, U.A., Glaubitz, C., Ludwig, B., Brutschy, B. and Tampé, R. (2011) Asymmetric ATP hydrolysis cycle of the heterodimeric multidrug ABC complex TmrAB from Thermus thermophiles. J. Biol. Chem. 286(9):7104-15

(5) Hellmich#, U.A. and Glaubitz, C. (2009) NMR and EPR on membrane transporters. Biol. Chem. 390(8), 815-34. Invited Review (#corresponding author)

(4) Pfleger, N., Wörner, A. C., Yang, J., Shastri, S., Hellmich, U.A., Aslimovska, L., Maier, M. S. M. and Glaubitz, C. (2009) Solid-state NMR and functional studies on Proteorhodopsin. Biochim. Biophys. Acta Bioenerg. 1787(6), 697-705

(3) Hellmich*, U.A., Pfleger*, N. and Glaubitz, C. (2009) 19F NMR on Proteorhodopsin: enhanced protocol for labeling for general application on membrane proteins. Photochem. Photobiol. 85(2), 535-539 (*contributed equally)

(2) Hellmich, U.A., Haase, W., Velamakanni, S., van Veen, H. W. and Glaubitz, C. (2008) Caught in the Act: ATP hydrolysis of an ABC multidrug transporter by real-time MAS NMR. Febs Lett. 23(23-24), 3557-3562

(1) Siarheyeva, A., Lopez, J. J., Lehner, I., Hellmich, U.A., van Veen, H. W. and Glaubitz, C. (2007) Probing the Molecular Dynamics of the ABC Multidrug Transporter LmrA by Deuterium Solid-State Nuclear Magnetic Resonance. Biochemistry 46(11); 3075-3083