In contrast to conventional drug carrier systems, sterically stabilized liposomes with PEG-corona provide several advantages, such as strongly reduced mononuclear phagocyte system (MPS) uptake, prolonged blood circulation time, reduced aggregation of the PEGylated vesicles and improved stability of the liposomal formulations. Similar to PEG, linear and hyperbranched polyglycerol (lPG and hbPG) show excellent biocompatibility, but in addition offer possibilities for further functionalization. Novel types of lipids modified with hyperbranched polyglycerol (hbPG), linear-hyperbranched PEG-hbPG block copolymers and random PEG-lPG copolymers have been prepared via the combined oxyanionic polymerization of different epoxide monomers using lipophilic initiators such as cholesterol and 1,2-bis-alkylglyceryl ether. The novel amphiphilic structures were successfully included into liposomal formulations emerging 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) as colipid.
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