Clinical Investigation Center

Head: Univ.-Prof. Dr. Oliver Tüscher





Tanja Darwiesh, study psychologist
Nehal Elnahrawy, assistant physician
Julius Grenz, assistant physician
Philipp Horstmann, assistant physician
Karolina Kurth, PhD student
Lara May, PhD student
Dr. Sandra Paryjas, scientist, CIC coordination
Danuta Weichert, study coordination 

Platform overview:
The Clinical Investigation Center's (CIC) central role within the DRZ is to longitudinally determine the main mental outcome measures and stressors, i.e., to assess and quantify resilience as described by us (Kalisch, Müller, Tüscher 2015, Kalisch et al. 2017) and is therefore the central organizational backbone for human studies at the DRZ. This central function is achieved by conducting the Gutenberg Brain Study (GBS) and its affiliated studies. Working in close collaboration with the NIC, as exemplified by the Mainz Resilience Project (MARP), it aims at identifying key neural mechanisms that predict resilient outcome and at probing the causal effect of these mechanisms on resilience via dedicated training interventions. Since resilience factors against everyday stressors have not systematically been defined, one focus is the development of proper measurement using cutting-edge ecological momentary assessment and intervention (EMA/EMI) technology. As the third major function performed for the DRZ, the CIC will support intervention studies, including psychological training programs, pharmacological trials or neurotechnical intervention (e.g., neurofeedback, transcranial stimulation).

Current research projects:

  • Resilience-focused evaluation of data from the Gutenberg Brain Study (GBS)
  • Supervision of the satellite studies of the GBS
  • Carrying out the human PRG-1 studies
  • Resilience and political participation
  • Establishment of ecological-valid instantaneous evaluation and intervention technology (AA and EMA / EMI)
  • Support of the central, longitudinal resilience studies MARP and LORA
  • Development of innovative non-invasive brain stimulation methods and pharmacological interventions to promote resilience
  • Implementation of a long-term study to capture resilience and investigate resilience factors (MARF)

External collaboration partners:

  • Univ.-Prof. Dr. Ines Germeys, Department of Neurosciences, Leuven, Belgium
  • Univ.-Prof. Dr. Hans Grabe, Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
  • Univ.-Prof. Dr. Martin Lotze, Baltic Neuroimaging Center, University Greifswald, Greifswald, Germany
  • Univ.-Prof. Dr. Henrik Walter, Department of Psychiatry and Psychotherapy, Humboldt University Berlin, Berlin, Germany


  • Ministry of Science of Rheinland Palatinate, Germany

Key Publications:

  • Vogt J, Yang JW, Mobascher A, Cheng J, Li Y, Liu X, Baumgart J, Thalman C, Kirischuk S, Unichenko P, Horta G, Radyushkin K, Stroh A, Richers S, Sahragard N, Distler U, Tenzer S, Qiao L, Lieb K, Tüscher O, Binder H, Ferreiros N, Tegeder I, Morris AJ, Gropa S, Nürnberg P, Toliat MR, Winterer G, Luhmann HJ, Huai J, Nitsch R (2016) Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP. EMBO Mol Med 8(1):25-38.
  • Kalisch R, Müller MB, Tüscher O (2015) Advancing empirical resilience research. Behav Brain Sci. 38:e128.
  • Kalisch R, Müller MB, Tüscher O (2015) From descriptive to mechanistic research in the field of resilience: a conceptual and practical framework for neurobiological and translational studies. Behav Brain Sci 38:e92.
  • Robbins M, Kubiak T (2014) Ecological Momentary Assessment in behavioural medicine research and practice. In D. Mostofsky (Ed.). Handbook of Behavioral Medicine (pp. 429-446). New York: Wiley-Blackwell.
  • Siewert K, Kubiak T, Jonas C, Weber H (2011) Trait anger moderates the impact of anger-associated rumination on social well-being. Personality and Individual Differences 51(6):769–774.