TP22N (Re)installing Cancer Immunity in pancreatic cancer and cancers of the upper GI tract
Özlem Türeci (Helmholtz Institut für Translationale Onkologie (HI-TRON)) & Matthias Gaida (Institut für Pathologie, Universitätsmedizin Mainz)
IRTG Integrated Research Training Group Tobias Bopp (Institut für Immunologie) & Björn Clausen (Institut für Molekulare Medizin) beide Universitätsmedizin Mainz
Z02 Central Tasks of the CRC,
Hansjörg Schild (Institut für Immunologie, Universitätsmedizin Mainz)
Completed projects
TP07E Defining the role of hepatocellular carcinoma-related epigenetic alterations driving immune evasion, Susanne Strand (I. Medical Center und Polyclinic, University Medical Center in Mainz) & Jens Marquardt (I. Medical Center, UKSH – Campus Lübeck)
TP14E Immunomodulation of cytomegalovirus latency and reactivation by regulatory T cells and dendritic cells, Rafaela Holtappels (Institute for Virology) & Björn Clausen (Institute for Molecular Medicine) both at the University Medical Center Mainz
Z01E Integrated OMICS and Bioinformatics Platform, Stefan Tenzer (Institute for Immunology, University Medical Center Mainz) & Valesca Bukur (TRON - Translational Onkology gGmbH)
Subprojects of the first funding period 2018-2021
TP01 (Bopp/Schmitt): ICER-steered transcriptional regulation in macrophage-driven immune evasion mechanisms of malignant melanoma
TP02 (Beling/Ruf): TF-PAR2 signaling in TLR3-induced lung inflammation and Coxsackievirus infection
TP04 (König): SAMHD1: Impact on inflammation and DNA damage response in HIV-1 and malignant diseases
TP05 (Rajalingam): Oncogenic MAPK signaling in regulating anti tumor immunity
TP06 (Munder/Theobald): Molecular T cell immunotherapy and inhibition of tumor immune escape mechanisms
TP07 (Strand/Marquardt): Defining the role of hepatocellular carcinoma-related epigenetic alterations driving immune evasion
TP08 (Sprinzl/Schuppan): Characterization and modulation of innate myeloid cells in hepatocellular carcinoma
TP09 (Schmidt/Zipp): Mechanisms of immune evasion by malignant glioma
TP10 (Graf/Ruf): Immune modulation by the endothelial protein C receptor (EPCR) in cancer progression
TP11 (Lemmermann/Reddehase): Viral evasion of innate and adaptive immune cells and ‘inbetweeners’
TP12 (Fulda/Ullrich): Overcoming inefficient tumor immunity by Smac mimetics
TP13 (Probst/Schild): Suppressive mechanisms of regulatory T cells controlling CD8+ T cells in steady state, cancer and chronic infection
TP14 (Holtappels/Clausen): Immunomodulation of cytomegalovirus latency and reactivation by regulatory T cells and dendritic cells
TP15 (von Stebut-Borschitz/Waisman): Mechanisms controlling Th17 and regulatory T cells in the anti-Leishmania response
TP16 (Greten): Functional analysis of IL-17RA signaling in colorectal carcinogenesis
TP17 (Kreiter/Sahin): Neo-epitope specific CD4+ T cells – Anti-tumoral mechanisms and their modulation
TP18 (Sparwasser): Inhibition of tumor-associated Regulatory T cells by microbial metabolites
Z01 (Tenzer/Bukur): Integrated OMICS and Bioinformatics Platform
IRTG (Bopp/Clausen): Integrated Research Training Group
