Dr. Eva-Maria Albers
Group Leader
Department of Molecular Cell Biology, JGU
Anselm Franz von Bentzelweg 3, 55128 Mainz
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Research Interests
We are interested in the molecular mechanisms of neuron-glia interaction and myelin biogenesis with implications in CNS disease. In particular we are studying in the role of vesicles termed exosomes in the communication between neural cells and also between the CNS and the periphery.
Key techniques: Cell culture, protein biochemistry, molecular biology, immunocytochemistry, cell fractionation, exosome isolation, qPCR
Research system/organism: Mouse
Five Most Relevant Publications
- Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius M, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers, EM (2013) Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLOS Biol, 11(7):e1001604.
- Feldmann A, Amphornrat J, Schönherr M, Winterstein C, Mobius W, Ruhwedel T, Danglot L, Nave KA, Galli T, Bruns D, Trotter J, Krämer-Albers EM (2011) Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7. J Neurosci 31:5659-5672.
- Krämer-Albers EM, White R (2011) From axon-glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase. Cell Mol Life Sci 68:2003-2012.
- Winterstein C, Trotter J, Krämer-Albers EM (2008) Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling. J Cell Sci 121:834-842.
- Krämer-Albers EM, Gehrig-Burger K, Thiele C, Trotter J, Nave KA (2006) Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia. J Neurosci 26:11743-11752.